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Rosetta and Mac OS X 10.7 (Lion) 09 05 11 If you have been following any of the discussions about the next Mac OS X operating system (Lion) you may have noticed that Rosetta is no longer supported. I am having a little bit of a different problem, trying to compile 3.5 in mavericks (mac os x 10.9) I installed scons succesfully. Cd'ing to the rosettasource dir, I do./scons.py -j8 mode=release bin. Mac OS X is the current incarnation of Mac OS. The first version released was Mac OS X Server in 1999. Unlike the classic Mac OS, Mac OS X is based on NeXTSTEP (OPENSTEP) and uses its frameworks and architectures. In 2016, Apple began to use the macOS moniker to brand Mac OS X alongside their other operating systems (watchOS, tvOS, iOS). On a Mac, you’d expect nothing less. The Universal truth. Most of the applications that come on your Intel-based Mac are Universal applications, designed for screaming performance with the Intel Core Duo. That includes Mac OS X, iLife, Safari and Mail. Most existing applications will continue to run, thanks to Rosetta.
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Download for MacOS - server 1 --> FreePyRosetta is available for Mac (64-bit OS X v10.5+) and Linux (64-bit Red Hat and 64-bit Ubuntu) platforms in continuous release versions (usually we have a fresh builds available daily). Running on Windows-10 (thought Unix layer) is are also supported. Additionally, both Python 2.7 and 3.5 is supported.
A PyRosetta license is required in order to download and use PyRosetta. Licensing is free for academic and non-profit institutions and is available to commercial users for a fee. Academic and commercial licensing of PyRosetta is handled the license similar to standard Rosetta license through Rosetta Commons. Please click [HERE] for more information.
Please use our forums for technical support and assistance or if you have any questions or problems with installing PyRosetta.
PyRosetta Build Information:

Latest PyRosetta Versions
Mac
Mac OS X 10.7 'Lion/MountainLion' (64-bit)[Python-3.6.Release] [Python-3.6.MinSizeRel] [Python-3.6.Debug] [Python-3.6.Release.wheel]
Windows 10
PyRosetta-4 Linux build work natively thought Win10 Linux layer. For installation details please see: Instructions for Installing PyRosetta on Windows 10PyMOL-RosettaServer scripts
[PyMOL-RosettaServer.python2]
[PyMOL-RosettaServer.python3]
RosettaCommons Conda Channel
The RosettaCommons conda channel provides conda packages for each weekly releases. Currently PyRosetta.release packages for Python 3.6 and 3.7 provided for both Mac and Linux platforms. Note that when possible we intend to keep all released packagesavailable(i.e old releases packages will not be deleted), so it should be safe to publish your results and use explicit PyRosetta version to ensure reproducibility. To use RosettaCommons channel edit your local ~/.condarc and add https://conda.graylab.jhu.eduinto your channels list. Then run conda install pyrosetta (or conda install pyrosetta=<version> if you want to install specific version of PyRosetta).
Example ~/.condarc:
PyRosetta Binaries in Git repositories use this if you want to frequently update PyRosetta version. (To upgrade simply run 'git pull' on checked out repository. Please note that Git history automatically truncated to store only ~2 last revisions to save disk space.)
To checkout repository with PyRosetta binaries use following command line (replacing 'login' with your user name):
% git clone https://[email protected]
So for example Mac command line will be:
% git clone https://[email protected]graylab.jhu.edu/download/PyRosetta4/git/release/PyRosetta4.Release.python27.mac.release.git
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In order to update these repositories, you must use:
% git fetch && git reset --hard origin/master && git clean -fd
For a full list of available git repositories please see: [PyRosetta-4, Git repositories] (you will need to enter your user name and password to access this page)
Other PyRosetta builds
Our release archive: [full list of available releases]
Binaries for older PyRosetta releases could be downloaded at: [PyRosetta3 Download]
System Requirements
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Build Support Information
PyRosetta is currently only supported on the platforms listed above. Users have sometimes been successful at installing PyRosetta on other platforms; please see the forums for more information, for example, the topic: Building PyRosetta for Linux Mint.
GNU/Linux
Python 2.7 or 3.5 for 64-bit LinuxMac OS X
v10.6+ and any Intel-based chipset MacWindows
Windows-10 or laterGNU/Linux and Mac OS X
pip
.) There are two major ways to install PyRosetta: either into your standard system Python, or using a Python environment manager. Installation into the system Python is easier and makes PyRosetta available at all times, though it makes upgrading PyRosetta more difficult and may require administrator access. Using an environment manager is more flexible and permits installation as a normal (non-admin) user, but requires more effort in understanding the system. - Obtain a Rosetta license fromto receive a username and password.
- Download the appropriate version of PyRosetta from the links above.
- Unpack the downloaded file to the location of your choice to create the PyRosetta directory.
(From a terminal/console window, you can unpack the archive using the command:tar -vjxf PyRosetta-<version>.tar.bz2
. - From within the new PyRosetta directory, type
cd setup && sudo python setup.py install
into the command line to set up the PyRosetta. - Start Python.
- In Python, you should be able to import the PyRosetta library with the command
import pyrosetta; pyrosetta.init()
.
(If this step does not produce a complaint or error, your installation has been successful.)
- Once you've installed PyRosetta, the downloaded PyRosetta archive file and the associated directory from steps 2 and 3 are no longer needed.
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Installation with an environment manager:
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Before beginning, be sure that your desired environment manager (e.g. conda or virtualenv) is installed in your system. Please see tutorials for the corresponding environment manager to learn how to install and use them.- Obtain a Rosetta license fromto receive a username and password.
- Download the appropriate version of PyRosetta from the links above.
- Using the environment manager, create a new environment for this version of PyRosetta. (conda; virtualenv)
(The corresponding version of Python should be the only dependency required.) - Activate the new environment.
- Unpack the downloaded file to the location of your choice to create the PyRosetta directory.
(From a terminal/console window, you can unpack the archive using the command:tar -vjxf PyRosetta-<version>.tar.bz2
. - From within the new PyRosetta directory, type
cd setup && python setup.py install
into the command line to set up the PyRosetta. - Start Python.
- In Python, you should be able to import the PyRosetta library with the command
import pyrosetta; pyrosetta.init()
.
(If this step does not produce a complaint or error, your installation has been successful.)
- Once you've installed PyRosetta, the downloaded PyRosetta archive file and the associated directory from steps 2 and 5 are no longer needed.
- If you installed PyRosetta within an environment manager, remember to re-activate the corresponding PyRosetta environment each time you wish to use PyRosetta.
Windows:
- Obtain a Rosetta license fromto receive a username and password.
- Follow the [Instructions for Installing PyRosetta on Windows 10]